STUDIES OF AMINO ACID METABOLISM

Amino Acid Metabolism

AB S T R A C T To evaluate the factors regulating gluconeogenesis in pregnancy, plasma amino acid levels were determined during the course of an 84-90 hr fast in physically healthy women studied during wk 16-22 of gestation (before undergoing therapeutic abortion), and in nonpregnant controls. The effect of pregnancy on the glycemic response to exogenous alanine administration during starvation...

The Effect of Amino Acid, Carbohydrate, and Lipid Metabolism Disorders on Eyes

Inherited metabolic disorders (IMDs) are a class of genetic disorders. Each metabolic disorder may have different forms with different age of onset, clinical manifestations, severity, and even type of inheritance. Ideally, a group of different specialists, including ophthalmologists, pediatricians, biochemists, and medical geneticists are needed for the final diagnosis and management of IMDs. B...

Malnutrition and Amino Acid Metabolism

Severe childhood malnutrition embraces a spectrum of clinical presentations and pathologic disorders. Across the entire spectrum, there is clear evidence of major changes in the state of amino acid and whole body protein metabolism, from the skeletal wasting and stunting of marasmus to the varied multisystem changes characterized by the kwashiorkor syndrome. For this reason, amino acid and prot...

The amino acid metabolism of Aspergillus flavus.

Disorders of branched chain amino acid metabolism

The three essential branched-chain amino acids (BCAAs), leucine, isoleucine and valine, share the first enzymatic steps in their metabolic pathways, including a reversible transamination followed by an irreversible oxidative decarboxylation to coenzyme-A derivatives. The respective oxidative pathways subsequently diverge and at the final steps yield acetyl- and/or propionyl-CoA that enter the K...